Raid and Mythic+ - Void-Scarred
The Season 2 default, and it is the default in both raid and keys rather than one of a pair. Void-Scarred shortens the gap between transformations through Soul Glutton, then pays you for entering them: Voidsurge turns each one into burst cleave you did not have to aim. It also folds the melee combo back in - Voidblade into Hungering Slash, with Voidstep resetting Vengeful Retreat - so you step in for a beat and leave, which suits Demon Hunter mobility and costs nothing when a mechanic pushes you out. Second Helping, Soulshaper, Moment of Craving and Devourer's Edge all sharpen Reap, which is the node everything else keys off. Take Eradicate when Reap needs to become an AoE tool.