This key is decided by spider-control discipline: protect the planned kick, do not accidentally chain nearby packs, and clear boss adds before they turn into permanent pressure.
Opening packs: reserve the real interrupt: Hold a kick for Ixin's Horrifying Shrill and never let a Sentry Stagshell finish Alarm Shrill. Web Bolt is a spare-kick spell; the fear and alarm are the casts that change the pull.
Avanoxx: control crawlers before meter damage: Kill or crowd-control Starved Crawlers before they reach Avanoxx. If she consumes one, Insatiable stacks and the pull rapidly becomes a healing and tank-survival problem. Use personals for Alerting Shrill and keep Vile Webbing out of the group path.
Anub'zekt: assign the volley and use the checkpoint: The Bloodstained Webmage's Revolting Volley is the priority kick before Anub'zekt. On the boss, use a defensive for Infestation, place the resulting swarm away from future movement, and interrupt Silken Restraints while cleaving the Webmages together.
These are execution priorities, not a fixed pull-count route. Verify weekly tuning, affixes, and your tank's route before the key, then use the source and current videos for difficulty-specific details.
Keep the arena traversable: sidestep Erupting Webs and do not turn the last boss into a rushed movement check by dropping avoidable ground effects in the center.